3-5 In clinical practice, treatment has most often been discontinued at an arbitrary time, with the subsequent coagulation profile monitored. 2,3 On the basis of clinical experience, we propose discontinuing vitamin K 1 treatment when a patient’s blood brodifacoum concentration is less than 10 ng per milliliter. Case reports indicate that the brodifacoum elimination half-life ranges from 16 to 62 days. 1 Serious brodifacoum poisoning is characterized by life-threatening hemorrhage.īrodifacoum poisoning is treated with vitamin K 1, but the treatment duration is variable, and thus management of the condition is challenging. The most trusted, influential source of new medical knowledge and clinical best practices in the world.īrodifacoum, a long-acting vitamin K epoxide cycle antagonist, is a rodenticide encountered in intentional ingestions and as a contaminant of some synthetic cannabinoid products. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making.
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